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Milademetan
Posters, Presentations & Publications
MDM2 inhibition in combination with MEK inhibition in pre-clinical models of lung adenocarcinomas with MDM2 amplification
Arielle Elkrief, Igor Odintsov, Vladimir Markov, Rebecca Caeser3, Pawel Sobczuk, Sam E. Tischfield, Umesh Bhanot, Emily Cheng, Alexander Drilon, Gregory J. Riely, William W. Lockwood, Elisa de Stanchina, Vijaya G. Tirunagaru, Robert C. Doebele, Álvaro Quintanal-Villalonga, Charles M. Rudin, Romel Somwar and Marc Ladanyi
MDM2 inhibition in combination with MEK inhibition in pre-clinical models of lung adenocarcinomas with MDM2 amplification
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MDM2 inhibitor milademetan: Safety profile and management of adverse events
Chiara Fabbroni, Robin L. Jones, Andrea Napolitano, Tammy Linback, Elaine MacNeilly, Feng Xu, Laetitia Simeral
MDM2 inhibitor milademetan: Safety profile and management of adverse events
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A First-in-Human Phase I Study of Milademetan, an MDM2 Inhibitor, in Patients With Advanced Liposarcoma, Solid Tumors, or Lymphomas
Mrinal M. Gounder, MD1; Todd M. Bauer, MD ; Gary K. Schwartz, MD ; Amy M. Weise, DO ; Patricia LoRusso, DO, PhD ; Prasanna Kumar, PhD ; Ben Tao, MS ; Ying Hong, PhD ; Parul Patel, MSc ; Yasong Lu, PhD ; Arnaud Lesegretain ; Vijaya G. Tirunagaru, PhD ; Feng Xu, MS ; Robert C. Doebele, MD, PhD ; and David S. Hong, MD
A First-in-Human Phase I Study of Milademetan, an MDM2 Inhibitor, in Patients With Advanced Liposarcoma, Solid Tumors, or Lymphomas
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SABCS 2022
Francois-Clement Bidard, Diana Bello Roufai, Arielle J. Medford, Vijaya G. Tirunagaru, Robert C. Doebele, Aditya Bardia
Genetic alterations in breast cancer associated with MDM2 dependency and sensitivity to the MDM2 inhibitor milademetan
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CTOS 2022
Mrinal M. Gounder, Amy M. Weise, Prasanna Kumar, Ben Tao, Arnaud Lesegretain, Vijaya G. Tirunagaru, Feng Xu, Richard Bryce, David S. Hong
Sustained disease control with MDM2 inhibitor milademetan in patients with advanced dedifferentiated liposarcoma
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ENA 2022
Vijaya G. Tirunagaru, Kanchan Singh, Xinyu Pei, Robert C. Doebele
Combination of MDM2 inhibition with milademetan and MEK inhibition leads to improved anti-tumor activity in cancer models harboring wild-type TP53
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ASCO 2022
Vijaya G. Tirunagaru, Feng Xu, Trista Hinz, Lynn E. Heasley, Richard Bryce, Avanish Vellanki, Nora Ku, and Robert C. Doebele
Using CDKN2A loss in the context of wild-type TP53 to predict sensitivity for the MDM2 inhibitor milademetan
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ASCO 2022
Mrinal M. Gounder, Gary K. Schwartz, Robin L. Jones, Sant P. Chawla, Victoria S. Chua-Alcala, Silvia Stacchiotti, Andrew J. Wagner, Gregory M. Cote, Robert G. Maki, Hanna Kosela-Paterczyk, Dale R. Shepard, Naisargee Shah, Richard Bryce, Robert C. Doebele, Shreyaskumar Patel
MANTRA: A randomized, multicenter, phase 3 study of the MDM2 inhibitor milademetan (RAIN-32) versus trabectedin in patients with dedifferentiated liposarcoma
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ASCO 2022
Ecaterina E. Dumbrava, Glenn J. Hanna, Gregory M. Cote, Thomas Stinchcombe, Melissa Johnson, Christopher T. Chen, Siddhartha Devarakonda, Naisargee Shah, Feng Xu, Robert C. Doebele, Mrinal M. Gounder
MANTRA-2: A phase 2 study of the MDM2 inhibitor milademetan in patients with TP53 wild-type and MDM2-amplified advanced or metastatic solid tumors
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AACR 2022
Mrinal M. Gounder, Gary K. Schwartz, Robin L. Jones, Sant P. Chawla, Victoria S. Chua-Alcala, Silvia Stacchiotti, Andrew J. Wagner, Gregory M. Cote, Robert G. Maki, Hanna Kosela-Paterczyk, Dale R. Shepard, Naisargee Shah, Richard Bryce, Robert C. Doebele, Shreyaskumar Patel
MANTRA: A randomized, multicenter, phase 3 study of the MDM2 inhibitor milademetan (RAIN-32) versus trabectedin in patients with dedifferentiated liposarcoma
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AACR 2022
Ecaterina E. Dumbrava, Glenn J. Hanna, Gregory M. Cote, Thomas Stinchcombe, Melissa Johnson, Christopher T. Chen, Siddhartha Devarakonda, Naisargee Shah, Feng Xu, Robert C. Doebele, Mrinal M. Gounder
MANTRA-2: A phase 2 study of the MDM2 inhibitor milademetan in patients with TP53 wild-type and MDM2-amplified advanced or metastatic solid tumors
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AACR 2022
Vijaya G. Tirunagaru, Feng Xu and Robert C. Doebele
Exploration of MDM2 gene amplification, co-mutation status, and prognosis in solid tumors
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AACR-NCI-EORTC 2021
Vijaya G. Tirunagaru, PH.D.
MDM2gene amplification as a predictive biomarker for the MDM2 inhibitor milademetan
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AACR-NCI-EORTC 2021
Vijaya Tirunagaru, Ph.D.
The MDM2 inhibitor milademetan induces synthetic lethality in GATA3 mutant, ER positive breast cancer
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AACR-NCI-EORTC 2021
Varsha Ananthapadmanabhan, Ph.D.
Milademetan is a potent, murine double minute 2 (MDM2) inhibitor, highly active in TP53 wild-type (p53WT) Merkel cell carcinoma (MCC) cell lines
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IASLC 2021 World Conference on Lung Cancer
Lynn Heasley, Ph.D.
The MDM2/p53 axis is a therapeutic vulnerability in malignant pleural mesothelioma
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EORTC-NCI-AACR 2020
Mrinal M. Gounder
Milademetan (DS-3032b or RAIN-32), an Oral MDM2 Inhibitor, in Well-Differentiated/Dedifferentiated Liposarcoma: Results From a Phase 1 Study in Patients With Solid Tumors or Lymphomas
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ASH 2019
Courtney D. DiNardo
A Phase 1 Dose-Escalation Study of Milademetan in Combination With 5-Azacitidine (AZA) in Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)
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ASH 2019
Naval Daver
A Phase 1 Study of Milademetan in Combination With Quizartinib in Patients With Newly Diagnosed (ND) or Relapsed/Refractory (R/R) FLT3-ITD Acute Myeloid Leukemia (AML)
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ESMO 2019
Toshio Shimizu
A Phase 2 biomarker-driven study evaluating the clinical efficacy of MDM2 inhibitor, milademetan, in patients with intimal sarcoma, a disease with a high unmet need
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